Innovative Pharmacological/Therapeutic Approaches against Hepatic Ischemia/Reperfusion Injury
نویسندگان
چکیده
1Department of Internal Medicine andTherapeutics, Pharmacology and Toxicology Unit, Via Ferrata 9A, 27100 Pavia, Italy 2Department of Pharmacology, Toxicology &Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, MS 1018, Kansas City, KS 66160, USA 3Department of Abdominal Transplant Surgery and Transplant Coordination, University Hospitals Leuven and Department of Microbiology and Immunology, University of Leuven, 3000 Leuven, Belgium 4Department of Surgery, Pharmacology andTherapeutics and Institute on Aging, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
منابع مشابه
Orexin-A Improves Hepatic Injury Following Renal Ischemia Reperfusion in Rats
Introduction: Orexins are novel neuropeptides that are localized in neurons in the lateral hypothalamus. They are implicated in a wide variety of physiological functions. Orexin peptides and receptors are found in many peripheral organs such as kidneys. It has been demonstrated that exogenous orexin-A can induce protective effects against ischemia–reperfusion injury in many organs. The goal ...
متن کاملHepatic Ischemia and Reperfusion Injury and Trauma: Current Concepts
CONTEXT Ischemia-reperfusion injury is a fascinating topic which has drawn a lot of interest in the last several years. Hepatic ischemia reperfusion injury may occur in a variety of clinical situations. These include transplantation, liver resection, trauma, and vascular surgery. EVIDENCE ACQUISITION The purpose of this review was to outline the molecular mechanisms underlying hepatic I/R inj...
متن کاملProtective effects of 2-methoxycinnamaldehyde an active ingredients of Cinnamomum cassia on warm hepatic ischemia reperfusion injury in rat model
Objective(s): Hepatic ischemia/reperfusion injury (IRI) is one of the major causes of hepatic failure during liver transplantation, trauma, and infections. The present study investigated the protective effect of intra-portal administration of 2-methoxycinnamaldehyde (2-MCA) on hepatic IRI in rats. Materials and Methods: Twenty-four rats ...
متن کاملIschemic preconditioning vs adenosine vs prostaglandin E1 for protection against liver ischemia/reperfusion injury
Ischemia/reperfusion injury is still a major cause of morbidity and mortality during liver surgery and transplantation. A variety of surgical and pharmacological therapeutic strategies have been investigated to minimize the effects of ischemia/reperfusion. The aim of our study was to analyze and compare preventive influences of ischemic preconditioning, adenosine and prostaglandin E1 in the exp...
متن کاملThe Role of Exercise Preconditioning in Cardioprotection against Ischemia Reperfusion Injury
Cardiovascular diseases are still the main cause of mortality around the world. Therefore, it is essential to develop practical means to reduce their burden. A wealth of evidence supports the role of physical exercise in attenuating many of the risk factors of cardiovascular diseases. Moreover, endurance training warrants protection against myocardial infarction. Exercise, even if performed ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2015 شماره
صفحات -
تاریخ انتشار 2015